產品編號 YB-1697R
英文名稱 Anti-alpha Defensin 1抗體
中文名稱 防御素α1/3抗體
別    名 Defensin, alpha 1; alpha Defensin 1/3; alpha Defensin 1+3; ; Defensin alpha 3; HNP1; HNP3; HP1; DEF1_HUMAN; Neutrophil defensin 1; HNP-1; HP-1; HP1; HP 1-56; Neutrophil defensin 1; Neutrophil defensin 2; HNP-2; HP-2; HP2; DEFA1; DEF1; DEFA2; MRS; DEF3_HUMAN; Neutrophil defensin 3; Defensin, alpha 3; HNP-3; HP-3; HP3; HP 3-56;
Anti-alpha Defensin 1抗體 
說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 6.7kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human alpha Defensin 1/3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
Defensins are a group of cyclic peptides containing 29-35 amino acids, which comprise approximay 30% of the total protein content of neutrophil azurophilic granules. Various functions have been reported for the defensins, including antibacterial and antifungal activity and chemotactic activity for monocytes.

Function:
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.

Subunit:
Dimer.

Subcellular Location:
Secreted.

Post-translational modifications:
ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production. 
Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-rybosylation.

Similarity:
Belongs to the alpha-defensin family.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.